Photosensitivity Due to Thiazides

Photosensitivity due to thiazides.

Thiazides are widely used diuretics that first became available in the 1950s. The first reports of photosensitivity reactions to thiazides were published shortly after the introduction of these drugs, but few cases have been described since. We review all the cases of photosensitivity due to thiazides published up to December 2011. We found 62 cases, 33 in women and 29 in men. The most common p...

Photosensitivity due to ampiroxicam.

Thiazides: do they kill?

In 2000 and 2002 after the ALLHAT-study had been published [1,2] there was a paradigm shift in the use of thiazides. ALLHAT was a study of cardiovascular endpoints in relation to different antihypertensive treatments in 33 357 hypertensive patients observed over an average of 4.9 years. The study [1,2] found no differences between the three treatment groups [diuretics in the form of chlorthalid...

Transient Worsening of Photosensitivity due to Cholelithiasis in a Variegate Porphyria Patient

Variegate porphyria (VP) is an autosomal dominant disease caused by mutations of the protoporphyrinogen oxidase (PPOX) gene. This porphyria has unique characteristics which can induce acute neurovisceral attacks and cutaneous lesions that may occur separately or together. We herin report a 58-years-old VP patient complicated with cholelithiasis. A sequencing analysis indicated a novel c.40G>C m...

Thiazides, beta blockers and lipoproteins.

Some of the more important recent studies on the effect of thiazides and beta-adrenoceptor blocking agents is conflicting, possibly because of differences in patient compliance and in lipoprotein methodology and quality assurance between studies. It is likely that in the short-term, thiazide diuretics produce an increase in plasma triglyceride and cholesterol and in LDL-cholesterol. No consiste...